Saturday, January 21, 2012

When a hormone that appears Exercise Can Create Weapon Against Diabetes

Sports not only make a sweaty, fit and maintain a fresh appearance. During exercise, the body also releases a hormone called alpha PGC1, which has efficacy as a weapon against obesity and diabetes.

The study was conducted by researchers at the Dana Farber Cancer Institute and Harvard Medical School. The results of these studies provide new insights on the effect of exercise on the body's cellular level.

The results of these studies have been published in the January 11, 2012 issue of Nature.

Scientists have examined a substance called alpha PGC1, which is produced in large amounts in the muscles during and after exercise. The cells that affect biological processes elsewhere in the body. The cells were predicted to be able to communicate with the fat body biochemistry.

"It seems clear that PGC1a stimulate many health benefits that are usually associated with age, obesity and diabetes," said Bruce Spiegelman, professor of cell biology and medicine at the Dana Farber Cancer Institute and Harvard Medical School as reported from TheNewYorkTimes, Thursday (12/1/2012 ).

The researchers used a sophisticated algorithm to determine that the increase in muscle causes PCG1a next bump in the expression of proteins known as Fndc5.

The Harvard researchers realized that, the protein was split into different pieces, one of which is a hormone that has not been identified.

The protein is called irisin by researchers. Irisin not entirely remain in the muscle. The protein enters the bloodstream and the fat cells to provide a variety of biochemical signals. The protein began to change on a regular basis in fat, particularly visceral fat, which clustered around the organs become brown fat.

"Irisin findings might contribute to the process of change in visceral fat into brown fat," said Sven Enerback, a professor of metabolic research at the University of Gothenburg in Sweden.

Brown fat, is physiologically desirable. Brown fat cells are metabolically active. Brown fat using oxygen and require energy and burn calories. Until now, he thinks that adults do not have brown fat, that fat loss after baby.

But some studies show that, adults are also hoards of brown fat. Some people also have more than others. Irisin and exercise, partly to determine how much brown fat. Irisin injected into white fat cells taken from mice. After that, the genetic alterations in cell signaling that occurs browning of white fat.

Fat cells also increased respiratory rate, which is an indication that burn more energy.

"In additional experiments with mice that were fattened, injections of proteins that go into irisin Fndc5, improve glucose tolerance," said Dr.. Spiegelman, they do not suffer from diabetes, despite being at increased risk of their diet.

In essence, irisin seems to be one missing link is more important in the understanding of how exercise can improve health.

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